• Alcohol‐attributed disease burden in four Nordic countries between 2000 and 2017: Are the gender gap s narrowing? A comparison using the Global Burden of Disease, Injury and Risk Factor 2017 study 

      Agardh, Emilie, E.; Allebeck, Peter; Flodin, Pär; Wenneberg, Peter; Ramstedt, Mats; Knudsen, Ann Kristin; Øverland, Simon Nygaard; Kinge, Jonas Minet; Tollånes, Mette C.; Eikemo, Terje Andreas; Skogen, Jens Christoffer; Mäkelä, Pia; Gissler, Mika; Juel, Knud; Iburg, Kim Moesgaard; McGrath, John J.; Naghavi, Mohsen; Vollset, Stein Emil; Gakidou, Emmanuela; Danielsson, Anna-Karin (Journal article; Peer reviewed, 2020)
      Introduction and Aims The gender difference in alcohol use seems to have narrowed in the Nordic countries, but it is not clear to what extent this may have affected differences in levels of harm. We compared gender ...
    • Alcohol‐attributed disease burden in four Nordic countries between 2000 and 2017: Are the gender gaps narrowing? A comparison using the Global Burden of Disease, Injury and Risk Factor 2017 study 

      Agardh, Emilie, E.; Allebeck, Peter; Flodin, Pär; Wenneberg, Peter; Ramstedt, Mats; Knudsen, Ann Kristin; Øverland, Simon Nygaard; Kinge, Jonas Minet; Tollånes, Mette C.; Eikemo, Terje Andreas; Skogen, Jens Christoffer; Mäkelä, Pia; Gissler, Mika; Juel, Knud; Iburg, Kim Moesgaard; McGrath, John J.; Naghavi, Mohsen; Vollset, Stein Emil; Gakidou, Emmanuela; Danielsson, Anna-Karin (Journal article; Peer reviewed, 2021)
      Introduction and Aims The gender difference in alcohol use seems to have narrowed in the Nordic countries, but it is not clear to what extent this may have affected differences in levels of harm. We compared gender ...
    • Antipsychotic drug use in pregnancy: A multinational study from ten countries 

      Reutfors, Johan; Cesta, Carolyn; Cohen, Jacqueline Mallory; Bateman, Brian T; Brauer, Ruth; Einarsdottir, Kristjana; Engeland, Anders; Furu, Kari; Gissler, Mika; Havard, Alys; Hernandez-Diaz, Sonia; Huybrechts, Krista F.; Karlstad, Øystein; Leinonen, Maarit; Li, Jiong; Man, Kenneth K. C.; Pazzagli, Laura; Schaffer, Andrea; Schink, Tania; Wang, Zixuan; Yu, Yongfu; Zoega, Helga; Bröms, Gabriella (Journal article; Peer reviewed, 2020)
      Aim To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. Methods Individually linked health data in Denmark (2000−2012), Finland (2005–2014), Iceland ...
    • Antipsychotic use in pregnancy and risk of attention/ deficit-hyperactivity disorder and autism spectrum disorder: a Nordic cohort study 

      Halfdanarson, Oskar; Cohen, Jacqueline Mallory; Karlstad, Øystein; Cesta, Carolyn E.; Bjørk, Marte-Helene; Håberg, Siri Eldevik; Einarsdottir, Kristjana; Furu, Kari; Gissler, Mika; Hjellvik, Vidar; Kieler, Helle; Leinonen, Maarit; Nørgaard, Mette; Essen, Buket Öztürk; Ulrichsen, Sinna Pilgaard; Reutfors, Johan; Zoega, Helga (Journal article; Peer reviewed, 2021)
      Background Antipsychotics are increasingly used among women of childbearing age and during pregnancy. Objective To determine whether children exposed to antipsychotics in utero are at increased risk of attention-d ...
    • Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability 

      Bjørk, Marte-Helene; Zoega, Helga; Leinonen, Maarit K.; Cohen, Jacqueline Mallory; Dreier, Julie Werenberg; Furu, Kari; Gilhus, Nils Erik; Gissler, Mika; Halfdanarson, Oskar; Igland, Jannicke; Sun, Yuelian; Tomson, Torbjörn; Alvestad, Silje; Christensen, Jakob (Journal article; Peer reviewed, 2022)
      Importance: Women with epilepsy frequently need antiseizure medication (ASM) to prevent seizures in pregnancy. Risk of neurodevelopmental disorders after prenatal exposure to AMSs is uncertain. Objective: To determine ...
    • Associations of pregnancy-related factors and birth characteristics with risk of endometrial cancer: A Nordic population-based case-control study 

      Trabert, Britton; Troisi, Rebecca; Grotmol, Tom; Ekbom, Anders; Engeland, Anders; Gissler, Mika; Glimelius, Ingrid; Madanat-Harjuoja, Laura M.; Sørensen, Henrik Toft; Tretli, Steinar; Ording, Anne Gulbech; Bjørge, Tone (Peer reviewed; Journal article, 2020)
      Many pregnancy‐related factors are associated with reduced endometrial cancer risk. However, it remains unclear whether pregnancy‐related complications (e.g., hypertensive conditions) are associated with risk and whether ...
    • Atomoxetine in Early Pregnancy and the Prevalence of Major Congenital Malformations: A Multinational Study 

      Bröms, Gabriella; Hernandez-Diaz, Sonia; Huybrechts, Krista F.; Bateman, Brian T.; Kristiansen, Eskild Bendix; Einarsdóttir, Kristjana; Engeland, Anders; Furu, Kari; Gissler, Mika; Karlsson, Pär; Klungsøyr, Kari; Lahesmaa-Korpinen, Anna-Maria; Mogun, Helen; Nørgaard, Mette; Reutfors, Johan; Sørensen, Henrik Toft; Zoega, Helga; Kieler, Helle (Journal article; Peer reviewed, 2023)
      Objective: Most research on safety of attention-deficit/ hyperactivity disorder (ADHD) medications during pregnancy concerns central nervous system stimulants, while little is known about the safety of atomoxetine, a primary ...
    • The burden of disease for children born alive with Turner syndrome—A European cohort study 

      Andersen, Ann-Louise Rud; Urhoj, Stine Kjaer; Tan, Joachim; Cavero-Carbonell, Clara; Gatt, Miriam; Gissler, Mika; Klungsøyr, Kari; Khoshnood, Babak; Morris, Joan; Neville, Amanda J.; Pierini, Anna; Scanlon, Ieuan; de Walle, Hermien E. K.; Wellesley, Diana; Garne, Ester; Loane, Maria (Journal article; Peer reviewed, 2023)
      Background Turner syndrome is a rare congenital anomaly caused by complete or partial X chromosome monosomy that may affect mortality and morbidity in childhood. Methods This population-based data-linkage cohort study, ...
    • Cancer risk in children of mothers with epilepsy and high-dose folic acid use during pregnancy 

      Vegrim, Håkon Magne; Dreier, Julie Werenberg; Alvestad, Silje; Gilhus, Nils Erik; Gissler, Mika; Igland, Jannicke; Leinonen, Maarit; Tomson, Torbjörn; Sun, Yuelian; Zoega, Helga; Christensen, Jakob; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)
      Importance: Women with epilepsy are recommended high doses of folic acid before and during pregnancy owing to risk of congenital anomalies associated with antiseizure medications. Whether prenatal exposure to high-dose ...
    • Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults 

      Daltveit, Dagrun Slettebø; Klungsøyr, Kari; Engeland, Anders; Ekbom, Anders; Gissler, Mika; Glimelius, Ingrid; Grotmol, Tom; Madanat-Harjuoja, Laura M.; Ording, Anne Gulbech; Sæther, Solbjørg Makalani Myrtveit; Sørensen, Henrik Toft; Troisi, Rebecca; Bjørge, Tone (Journal article; Peer reviewed, 2020)
      Objective To examine associations between birth defects and cancer from birth into adulthood. Design Population based nested case-control study. Setting Nationwide health registries in Denmark, Finland, Norway, ...
    • Cancer risk in the siblings of individuals with major birth defects: a large Nordic population-based case-control study 

      Daltveit, Dagrun Slettebø; Klungsøyr, Kari; Engeland, Anders; Ekbom, Anders; Gissler, Mika; Glimelius, Ingrid; Grotmol, Tom; Madanat-Harjuoja, Laura; Ording, Anne Gulbech; Sørensen, Henrik Toft; Troisi, Rebecca; Bjørge, Tone (Journal article; Peer reviewed, 2023)
      Background: Individuals with major birth defects are at increased risk of developing cancer, indicating a common aetiology. However, whether the siblings of individuals with birth defects are also at an increased risk of ...
    • Causes of death in children with congenital anomalies up to age 10 in eight European countries 

      Rissmann, Anke; Tan, Joachim; Glinianaia, Svetlana V; Rankin, Judith; Pierini, Anna; Santoro, Michele; Coi, Alessio; Garne, Ester; Loane, Maria; Given, Joanne; Reid, Abigail; Aizpurua, Amaia; Akhmedzhanova, Diana; Ballardini, Elisa; Barisic, Ingeborg; Cavero-Carbonell, Clara; De Walle, Hermien E K; Gatt, Miriam; Gissler, Mika; Heino, Anna; Jordan, Sue; Urhoj, Stine Kjaer; Klungsøyr, Kari; Lutke, Renee; Mokoroa, Olatz; Neville, Amanda Julie; Thayer, Daniel S; Wellesley, Diana G; Yevtushok, Lyubov; Zurriaga, Oscar; Morris, Joan (Journal article; Peer reviewed, 2023)
      Background Congenital anomalies (CAs) increase the risk of death during infancy and childhood. This study aimed to evaluate the accuracy of using death certificates to estimate the burden of CAs on mortality for children ...
    • Clarity and consistency in stillbirth reporting in Europe: why is it so hard to get this right? 

      Gissler, Mika; Durox, Mélanie; Smith, Lucy; Blondel, Béatrice; Broeders, Lisa; Hindori-Mohangoo, Ashna D.; Kearns, Karen; Kolarova, Rumyana; Loghi, Marzia; Rodin, Urelija; Szamotulska, Katarzyna; Velebil, Petr; Zurriaga, Oscar; Zeitlin, Jennifer; Klungsøyr, Kari (Journal article; Peer reviewed, 2022)
      Background Stillbirth is a major public health problem, but measurement remains a challenge even in high-income countries. We compared routine stillbirth statistics in Europe reported by Eurostat with data from the ...
    • Comparative Risk of Major Congenital Malformations With Antiseizure Medication Combinations vs Valproate Monotherapy in Pregnancy 

      Cohen, Jacqueline Mallory; Alvestad, Silje; Suarez, Elizabeth A.; Schaffer, Andrea; Selmer, Randi M.; Havard, Alys; Bateman, Brian T.; Cesta, Carolyn E.; Zoega, Helga; Odsbu, Ingvild; Huybrechts, Krista F.; Kjerpeseth, Lars J.; Straub, Loreen; Leinonen, Maarit K.; Bjørk, Marte-Helene; Nørgaard, Mette; Gissler, Mika; Ulrichsen, Sinna P.; Hernandez-Diaz, Sonia; Tomson, Torbjörn; Furu, Kari (Journal article; Peer reviewed, 2023)
      Background and Objectives Valproate should be avoided in pregnancy, but it is the most effective drug for generalized epilepsies. Alternative treatment may require combinations of other drugs. Our objectives were to ...
    • Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations 

      Cohen, Jacqueline Mallory; Alvestad, Silje; Cesta, Carolyn E.; Bjørk, Marte-Helene; Leinonen, Maarit; Nørgaard, Mette; Einarsdóttir, Kristjana; Engeland, Anders; Gissler, Mika; Karlstad, Øystein; Klungsøyr, Kari; Odsbu, Ingvild; Reutfors, Johan; Selmer, Randi Marie; Tomson, Torbjörn; Ulrichsen, Sinna Pilgaard; Zoega, Helga; Furu, Kari (Journal article; Peer reviewed, 2022)
      Objective: This study was undertaken to examine the comparative safety of antiseizure medication (ASM) monotherapy in pregnancy with respect to risk of major congenital malformations (MCMs), overall and by MCM subtype. ...
    • COVID-19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries 

      Engjom, Hilde Marie; Aabakke, Anna J. M.; Klungsøyr, Kari; Svanvik, Teresia; Äyräs, Outi; Jonasdottir, Eva; Thurn, Lars; Jones, Elin; Pettersson, Karin; Nyfløt, Lill Trine; Al-Zirqi, Iqbal Ahmad Abdelwahab; Vangen, Siri; Juliusson, Pétur Benedikt; Källén, Karin; Gissler, Mika; Krebs, Lone (Journal article; Peer reviewed, 2021)
      Introduction Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems. Material and ...
    • Determinants of long-term unemployment in early adulthood: A Finnish birth cohort study 

      Lallukka, Tea; Kerkelä, Martta; Ristikari, Tiina; Merikukka, Marko; Hiilamo, Heikki; Virtanen, Marianna; Øverland, Simon Nygaard; Gissler, Mika; Halonen, Jaana I (Peer reviewed; Journal article, 2019-08)
      Cumulative contributions of social and health-related determinants to long-term unemployment during early working life among young adults are poorly understood. Therefore, we used four cumulative indices of both parental ...
    • Differences in perinatal and infant mortality in high-income countries: Artifacts of birth registration or evidence of true differences? 

      Deb-Rinker, Paromita; León, Juan Andrés; Gilbert, Nicolas L.; Rouleau, Jocelyn; Andersen, Anne-Marie Nybo; Bjarnadóttir, Ragnheiður I.; Gissler, Mika; Mortensen, Laust H.; Skjaerven, Rolv; Vollset, Stein Emil; Zhang, Xun; Shah, Prakesh S.; Sauve, Reg S.; Kramer, Michael S.; Joseph, K.S. (Peer reviewed; Journal article, 2015-09-04)
      Background: Variation in birth registration criteria may compromise international comparisons of fetal and infant mortality. We examined the effect of birth registration practices on fetal and infant mortality rates to ...
    • Disease Burden Attributed to Drug use in the Nordic Countries: a Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 

      Agardh, Emilie, E.; Allebeck, Peter; Knudsen, Ann Kristin Skrindo; Aronsson, Emma Amanda; Flodin, Pär; Eikemo, Terje Andreas; Bangah, Paul R.; Skogen, Jens Christoffer; Gissler, Mika; Rönkä, Sanna; McGrath, John J.; Sigurvinsdottir, Rannveig; Dadras, Omid; Deuba, Keshab; Hedna, Khedidja; Mentis, Alexios‑Fotios A.; Sagoe, Dominic; Shiri, Rahman; Weye, Nanna Ørslev; Hay, Simon I.; Murray, Christopher J. L.; Naghavi, Mohsen; Pasovic, Maja; Vos, Theo; Wennberg, Peter; Danielsson, Anna‑Karin (Journal article; Peer reviewed, 2023)
      The Nordic countries share similarities in many social and welfare domains, but drug policies have varied over time and between countries. We wanted to compare differences in mortality and disease burden attributed to drug ...
    • Folic Acid and Risk of Preterm Birth, Preeclampsia, and Fetal Growth Restriction Among Women With Epilepsy A Prospective Cohort Study 

      Alvestad, Silje; Husebye, Elisabeth Synnøve Nilsen; Christensen, Jakob; Dreier, Julie Werenberg; Sun, Yuelian; Igland, Jannicke; Leinonen, Maarit; Gissler, Mika; Gilhus, Nils Erik; Tomson, Torbjörn; Bjørk, Marte-Helene (Journal article; Peer reviewed, 2022)
      Background and Objectives Women with epilepsy treated with antiseizure medication (ASM) have increased risk of pregnancy complications including preterm birth, fetal growth restriction, and preeclampsia. We aimed to ...